Combination of pharmacophore hypothesis, genetic function approximation model, and molecular docking to identify novel inhibitors of S6K1-Reference-Cited by-同舟云学术

Combination of pharmacophore hypothesis, genetic function approximation model, and molecular docking to identify novel inhibitors of S6K1

Published:2013-08-28 Issue:4 Volume:17 Page:767-772
ISSN:1381-1991
Container-title:Molecular Diversity
language:en
Short-container-title:Mol Divers

Author:

Zhang Hui,Xiang Ming-Li,Liang Jun-Yu,Zeng Tao,Zhang Xiao-Nuo,Zhang Ji,Yang Sheng-Yong

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Link

http://link.springer.com/content/pdf/10.1007/s11030-013-9473-7.pdf

Reference30 articles.

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2. Xu XY, Zhang Z, Su WH, Zhang Y, Yu YQ, Li YX, Zong ZH, Yu BZ (2009) Characterization of p70 S6 Kinase 1 in early development of mouse embryos. Dev Dyn 238:3025–3034. doi: 10.1002/dvdy.22131

3. Jacinto E, Hall MN (2003) Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 4:117–126. doi: 10.1038/nrm1018

4. Um SH, Frigerio F, Watanabe M, Fdr Picard, Joaquin M, Sticker M, Fumagalli S, Allegrini PR, Kozma SC, Auwerx J, Thomas G (2004) Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431:200–205. doi: 10.1038/nature02866

5. Wilson KF, Wu WJ, Wu RA (2006) Cdc42 stimulates RNA splicing via the S6 kinase and a novel S6 kinase target, the nuclear cap-binding complex. J Biol Chem 275:37307–37310. doi: 10.1074/jbc

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