Computer-aided discovery of phenylpyrazole based amides as potent S6K1 inhibitors
Author:
Affiliation:
1. School of Chemical and Environmental Engineering
2. Shanghai Institute of Technology
3. Shanghai
4. P. R. China
5. Medicinal Chemistry
6. The Scripps Research Institute
7. Jupiter
8. USA
9. Reaction Biology Corporation
Abstract
Ribosomal protein S6 kinase beta-1 (S6K1) is an attractive therapeutic target.
Funder
National Natural Science Foundation of China
Publisher
Royal Society of Chemistry (RSC)
Subject
Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry
Link
http://pubs.rsc.org/en/content/articlepdf/2020/MD/C9MD00537D
Reference21 articles.
1. Methionine Deprivation Regulates the S6K1 Pathway and Protein Synthesis in Avian QM7 Myoblasts without Activating the GCN2/eIF2 alpha Cascade
2. The Р60-S6K1 isoform of ribosomal protein S6 kinase 1 is a product of alternative mRNA translation
3. Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice
4. Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
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