Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase-Reference-Cited by-同舟云学术

Docking-based 3D-QSAR and pharmacophore studies on diarylpyrimidines as non-nucleoside inhibitors of HIV-1 reverse transcriptase

Published:2018-07-26 Issue:1 Volume:23 Page:107-121
ISSN:1381-1991
Container-title:Molecular Diversity
language:en
Short-container-title:Mol Divers

Author:

Liu Genyan,Wan Youlan,Wang Wenjie,Fang Sai,Gu Shuangxi,Ju Xiulian

Funder

Graduate Innovative Fund of Wuhan Institute of Technology

Natural Science Foundation of Hubei Province of China

Hubei Provincial Department of Education of China

Wuhan International Scientific and Technological Cooperation Project

National Natural Science Foundation of China

Publisher

Springer Science and Business Media LLC

Subject

Inorganic Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Drug Discovery,Molecular Biology,General Medicine,Information Systems,Catalysis

Link

http://link.springer.com/article/10.1007/s11030-018-9860-1/fulltext.html

Reference39 articles.

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2. Chong P, Sebahar P, Youngman M, Garrido D, Zhang H, Stewart EL, Nolte RT, Wang L, Ferris RG, Edelstein M (2012) Rational design of potent non-nucleoside inhibitors of HIV-1 reverse transcriptase. J Med Chem 55:10601–10609. https://doi.org/10.1021/jm301294g

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4. Kohlstaedt LA, Wang J, Friedman JM, Rice PA, Steitz TA (1992) Crystal structure at 3.5 Å resolution of HIV-1 reverse transcriptase complexed with an inhibitor. Science 256:1783–1790. https://doi.org/10.1126/science.1377403

5. Hsiou Y, Ding J, Das K, Clark JA, Hughes S, Arnold E (1996) Structure of unliganded HIV-1 reverse transcriptase at 2.7 Å resolution: implications of conformational changes for polymerization and inhibition mechanisms. Structure 4:853–860. https://doi.org/10.1016/S0969-2126(96)00091-3

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