Phase I study of irinotecan by 24-h intravenous infusion in combination with 5-fluorouracil in metastatic colorectal cancer

Author:

Kambe Mariko,Kikuchi Hiroaki,Gamo Makio,Yoshioka Takashi,Ohashi Yasuo,Kanamaru Ryunosuke

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Hematology,General Medicine,Surgery

Reference14 articles.

1. Kawato Y, Aonuma M, Hirota Y et al (1991) Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res 51:4187–4191

2. Sylvie G, Daniel C, Isabelle H et al (1997) Sequence-dependent activity of the irinotecan-5FU combination in human colon-cancer model HT-29 in vitro and in vivo. Int J Cancer 73:729–734

3. Loffler TM, Drogen C, Hausamen TU (1999) Weekly 24-hours infusion irinotecan (CPT-11) in 5-FU pretreated metastatic colorectal cancer. Proc Am Soc Clin Oncol 18:240a (abstract 922)

4. Saltz LB, Cox JV, Blanke C et al (2000) Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. N Engl J Med 343:905–914

5. Douillard JY, Cunningham D, Roth AD et al (2000) Irinotecan combined with fluorouracil compared with fluorouracil alone as first line treatment for metastatic colorectal cancer: a multicenter randomised trial. Lancet 355:1041–1047

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