The Organogermanium Compound Ge-132 Interacts with Nucleic Acid Components and Inhibits the Catalysis of Adenosine Substrate by Adenosine Deaminase

Author:

Shimada YasuhiroORCID,Sato Katsuyuki,Takeda Tomoya,Tokuji Yoshihiko

Publisher

Springer Science and Business Media LLC

Subject

Biochemistry (medical),Inorganic Chemistry,Clinical Biochemistry,General Medicine,Biochemistry,Endocrinology, Diabetes and Metabolism

Reference41 articles.

1. Brutkiewicz RR, Suzuki F (1987) Biological activities and antitumor mechanism of an immunopotentiating organogermanium compound, Ge-132. In Vivo 1:189–203

2. Tsutsui M, Kakimoto N, Axtell DD, Oikawa H, Asai K (1976) Crystal structure of “carboxyethylgermanium sesquioxide.”. J Am Chem Soc 98:8287–8289

3. Nagata T, Nagata T, Aramaki Y, Enomoto M, Isaka H, Otsuka J (1978) Chronic intravenously toxicity study with carboxyethylgermanium sesquioxide in beagle dogs. Pharmacometrics 16:613–636

4. Sugiya Y, Sakamaki S, Sugita T, Abo Y, Satoh H (1986) Subacute oral toxicity of carboxyethylgermanium sesquioxide (Ge-132) in rats. Ouyou Yakuri 31:1181–1190 (in Japanese)

5. Miyao K, Onishi T, Asai K, Tomizawa S, Suzuki F (1980) Toxicology and phase I studies on a novel organogermanium compound, Ge-132. Curr Chemother Infect Dis 2:1527–1529

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