Mitochondrial Dysfunction as a Signaling Target for Therapeutic Intervention in Major Neurodegenerative Disease

Author:

Mangrulkar Shubhada V.,Wankhede Nitu L.,Kale Mayur B.,Upaganlawar Aman B.,Taksande Brijesh G.,Umekar Milind J.,Anwer Md. Khalid,Dailah Hamad Ghaleb,Mohan Syam,Behl Tapan

Publisher

Springer Science and Business Media LLC

Subject

Toxicology,General Neuroscience

Reference220 articles.

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2. Akbar M, Essa MM, Daradkeh G, Abdelmegeed MA, Choi Y, Mahmood L, Song BJ (2016) Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res 1637:34–55. https://doi.org/10.1016/j.brainres.2016.02.016

3. Aliev G, Seyidova D, Lamb BT, Obrenovich ME, Siedlak SL, Vinters HV, Friedland RP, LaManna JC, Smith MA, Perry G (2003) Mitochondria and vascular lesions as a central target for the development of Alzheimer’s disease and Alzheimer disease-like pathology in transgenic mice. Neurol Res 25:665–674. https://doi.org/10.1179/016164103101201977

4. Allen SP, Hall B, Woof R, Francis L, Gatto N, Shaw AC, Myszczynska M, Hemingway J, Coldicott I, Willcock A, Job L, Hughes RM, Boschian C, Bayatti N, Heath PR, Bandmann O, Mortiboys H, Ferraiuolo L, Shaw PJ (2019) C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis. Brain 142:3771–3790. https://doi.org/10.1093/BRAIN/AWZ302

5. Altanbyek V, Cha SJ, Kang GU, Im DS, Lee S, Kim HJ, Kim K (2016) Imbalance of mitochondrial dynamics in Drosophila models of amyotrophic lateral sclerosis. Biochem Biophys Res Commun 481:259–264. https://doi.org/10.1016/J.BBRC.2016.10.134

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