Evaluation of repeated or acute treatment with cannabidiol (CBD), cannabidiolic acid (CBDA) or CBDA methyl ester (HU-580) on nausea and/or vomiting in rats and shrews

Author:

Rock Erin M.,Sullivan Megan T.,Collins Stephen A.,Goodman Hannah,Limebeer Cheryl L.,Mechoulam Raphael,Parker Linda A.ORCID

Funder

Natural Sciences and Engineering Research Council of Canada

Canadian Institutes of Health Research

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology

Reference47 articles.

1. Anderson LL, Low IK, Banister SD, McGregor IS, Arnold JC (2019) Pharmacokinetics of phytocannabinoid acids and anticonvulsant effect of cannabidiolic acid in a mouse model of Dravet syndrome. J Nat Prod 82:3047–3055. https://doi.org/10.1021/acs.jnatprod.9b00600

2. Araz M, Karaagac M, Korkmaz L, Koral L, Inci F, Beypinar I, Uysal M, Artac M (2019) Comparison of palonosetron and granisetron in triplet antiemetic therapy in nonmetastatic breast cancer patients receiving high emetogenic chemotherapy: a multicenter, prospective, and observational study. Cancer Chemother Pharmacol 83:1091–1097. https://doi.org/10.1007/s00280-019-03831-4

3. Bolognini D, Rock EM, Cluny NL, Cascio MG, Limebeer CL, Duncan M, Stott CG, Javid FA, Parker LA, Pertwee RG (2013) Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation. Br J Pharmacol 168:1456–1470. https://doi.org/10.1111/bph.12043

4. Campos AC, de Paula SV, Carvalho MC, Ferreira FR, Vicente MA, Brandão ML, Zuardi AW, Zangrossi H Jr, Guimarães FS (2013) Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats. Psychopharmacology 226:13–24. https://doi.org/10.1007/s00213-012-2878-7

5. Campos AC, Fogaça MV, Sonego AB, Guimarães FS (2016) Cannabidiol, neuroprotection and neuropsychiatric disorders. Pharmacol Res 112:119–127. https://doi.org/10.1016/j.phrs.2016.01.033

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