Cannabidiolic acid prevents vomiting inSuncus murinusand nausea-induced behaviour in rats by enhancing 5-HT1Areceptor activation

Author:

Bolognini D1,Rock EM2,Cluny NL3,Cascio MG1,Limebeer CL2,Duncan M4,Stott CG4,Javid FA5,Parker LA2,Pertwee RG1

Affiliation:

1. Institute of Medical Sciences; University of Aberdeen; Aberdeen; UK

2. Department of Psychology and Neuroscience Graduate Program; University of Guelph; Guelph; ON; Canada

3. Department of Physiology and Pharmacology; University of Calgary; Calgary; AB; Canada

4. Sovereign House; GW Research Ltd; Cambridge; UK

5. Division of Pharmacy and Pharmaceutical Sciences; School of Applied Sciences; University of Huddersfield; Huddersfield; UK

Publisher

Wiley

Subject

Pharmacology

Reference65 articles.

1. Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids;Anavi-Goffer;J Biol Chem,2012

2. Impact of nausea and vomiting on quality of life in cancer patients during chemotherapy;Ballatori;Health Qual Life Outcomes,2003

3. Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists;Boer-Dennert;Br J Cancer,1997

4. Bolognini D Rock EM Cascio MG Parker L Pertwee RG 2012 Cannabidiolic acid behaves as a highly potent enhancer of 5-HT 1A receptor activation both in vitro and in vivo 22nd Annual Symposium of the Cannabinoids 43

5. Involvement of 5HT1A receptors in the anxiolytic-like effects of cannabidiol injected into the dorsolateral periaqueductal gray of rats;Campos;Psychopharmacology,2008

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