A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression-Reference-Cited by-同舟云学术

A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression

Published:2018-12-18 Issue:3 Volume:68 Page:421-432
ISSN:0340-7004
Container-title:Cancer Immunology, Immunotherapy
language:en
Short-container-title:Cancer Immunol Immunother

Author:

Mahoney Kathleen M.^ORCID,Shukla Sachet A.^ORCID,Patsoukis Nikolaos^ORCID,Chaudhri Apoorvi^ORCID,Browne Edward P.^ORCID,Arazi Arnon,Eisenhaure Thomas M.^ORCID,Pendergraft William F.,Hua Ping,Pham Hung C.,Bu Xia,Zhu Baogong,Hacohen Nir^ORCID,Fritsch Edward F.,Boussiotis Vassiliki A.^ORCID,Wu Catherine J.^ORCID,Freeman Gordon J.^ORCID

Funder

DF/HCC Kidney Cancer SPORE

Claudia Adams Barr Program for Innovative Cancer Research

2014 AACR Basic Cancer Research Fellowship

2014 ASCO Young Investigator Award supported by Kidney Cancer Association

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Oncology,Immunology,Immunology and Allergy

Link

http://link.springer.com/content/pdf/10.1007/s00262-018-2282-1.pdf

Reference36 articles.

1. Mahoney KM et al (2016) A secreted PD-L1 splice variant expressed across tumor types inhibits lymphocyte function. J Immunother Cancer 4(Suppl 1):82 (Poster)

2. Mahoney KM et al (2018) A secreted PD-L1 splice variant that covalently dimerizes and mediates immunosuppression. Kidney Cancer Symposium, November 3, 2018, Miami, Florida (oral presentation)

3. Freeman GJ et al (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med 192(7):1027–1034

4. Thompson RH et al (2006) Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up. Cancer Res 66(7):3381–3385

5. Finkelmeier F et al (2016) High levels of the soluble programmed death-ligand (sPD-L1) identify hepatocellular carcinoma patients with a poor prognosis. Eur J Cancer 59:152–159

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