Abstract
Abstract
Purpose of Review
Clinically significant portal hypertension (CSPH) is a serious clinical condition causing decompensation and potentially fatal complications especially in the presence of advanced liver disease. This article aims to critically review the current literature on non-invasive assessment of CSPH.
Recent Findings
The Baveno VII consensus encouraged non-invasive assessment of CSPH to identify patients at risk and avoid unnecessary screening endoscopies. Novel machine learning and omics-based laboratory scores have been introduced, which can be combined with liver stiffness measurement (LSM). Spleen stiffness measurement (SSM) is an increasingly used novel elastography modality. Elastography and cross-sectional imaging methods have reached similar predictive power, while the accuracy of non-invasive tests can only be improved when used sequentially.
Summary
In this review, we provide a detailed discussion of advantages and limitations of non-invasive assessment of CSPH, highlighting their diagnostic accuracy, reproducibility, and feasibility in clinical practice.
Funder
Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Hessisches Ministerium für Wissenschaft und Kunst
Horizon 2020 Framework Programme
Westfälische Wilhelms-Universität Münster
Publisher
Springer Science and Business Media LLC