Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct-Reference-Cited by-同舟云学术

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Increased CD74 binding and EAE treatment efficacy of a modified DRα1 molecular construct

Published:2018-10-23 Issue:1 Volume:34 Page:153-164
ISSN:0885-7490
Container-title:Metabolic Brain Disease
language:en
Short-container-title:Metab Brain Dis

Author:

Meza-Romero Roberto,Benedek Gil,Gerstner Grant,Kent Gail,Nguyen Ha,Offner Halina,Vandenbark Arthur A.

Funder

U.S. Department of Veterans Affairs

National Institute of Allergy and Infectious Diseases

National Institute of Neurological Disorders and Stroke

American Heart Association

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology (clinical),Biochemistry

Link

http://link.springer.com/article/10.1007/s11011-018-0331-2/fulltext.html

Reference25 articles.

1. Benedek G et al (2013) Partial MHC class II constructs inhibit MIF/CD74 binding and downstream effects. Eur J Immunol 43:1309–1321. https://doi.org/10.1002/eji.201243162

2. Benedek G, Meza-Romero R, Jordan K, Keenlyside L, Offner H, Vandenbark AA (2015) HLA-DRalpha1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection. J Neuroinflammation 12:123. https://doi.org/10.1186/s12974-015-0342-4

3. Benedek G et al (2017) MIF and D-DT are potential disease severity modifiers in male MS subjects. Proc Natl Acad Sci U S A 114:E8421–E8429. https://doi.org/10.1073/pnas.1712288114

4. Chitnis T (2007) The role of CD4 T cells in the pathogenesis of multiple sclerosis. Int Rev Neurobiol 79:43–72. https://doi.org/10.1016/S0074-7742(07)79003-7

5. Frohman EM, Racke MK, Raine CS (2006) Multiple sclerosis--the plaque and its pathogenesis. N Engl J Med 354:942–955. https://doi.org/10.1056/NEJMra052130

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