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Regulation of Anxiety and Depression by Mitochondrial Translocator Protein-Mediated Steroidogenesis: the Role of Neurons

  • Published:2020-09-29 Issue:2 Volume:58 Page:550-563
  • ISSN:0893-7648
  • Container-title:Molecular Neurobiology
  • language:en
  • Short-container-title:Mol Neurobiol

Author:

Barron Anna M.,Higuchi Makoto,Hattori Satoko,Kito Seiji,Suhara Tetsuya,Ji BinORCID

Funder

JSPS

the Ministry of Education, Culture, Sports, Science and Technology of Japan

Grants-in-Aid for Japan Advanced Molecular Imaging Program, Strategic Research Program for Brain Sciences

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Reference57 articles.

1. Rupprecht R, Papadopoulos V, Rammes G, Baghai TC, Fan J, Akula N, Groyer G, Adams D, Schumacher M (2010) Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders. Nature Reviews Drug Discovery 9 (12):971-988. doi:http://www.nature.com/nrd/journal/v9/n12/suppinfo/nrd3295_S1.html

2. Pini S, Martini C, Abelli M, Muti M, Gesi C, Montali M, Chelli B, Lucacchini A et al (2005) Peripheral-type benzodiazepine receptor binding sites in platelets of patients with panic disorder associated to separation anxiety symptoms. Psychopharmacology 181(2):407–411. https://doi.org/10.1007/s00213-005-2247-x

3. Abelli M, Chelli B, Costa B, Lari L, Cardini A, Gesi C, Muti M, Lucacchini A et al (2010) Reductions in platelet 18-kDa translocator protein density are associated with adult separation anxiety in patients with bipolar disorder. Neuropsychobiology 62(2):98–103. https://doi.org/10.1159/000315440

4. Costa B, Pini S, Martini C, Abelli M, Gabelloni P, Landi S, Muti M, Gesi C et al (2009) Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatr Genet 19(2):110–111. https://doi.org/10.1097/YPG.0b013e32832080f6

5. Colasanti A, Owen DR, Grozeva D, Rabiner EA, Matthews PM, Craddock N, Young AH (2013) Bipolar disorder is associated with the rs6971 polymorphism in the gene encoding 18 kDa translocator protein (TSPO). Psychoneuroendocrinology 38(11):2826–2829. https://doi.org/10.1016/j.psyneuen.2013.07.007
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