Sustained Hyperammonemia Activates NF-κB in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy-Reference-Cited by-同舟云学术

Sustained Hyperammonemia Activates NF-κB in Purkinje Neurons Through Activation of the TrkB-PI3K-AKT Pathway by Microglia-Derived BDNF in a Rat Model of Minimal Hepatic Encephalopathy

Published:2023-02-15 Issue:6 Volume:60 Page:3071-3085
ISSN:0893-7648
Container-title:Molecular Neurobiology
language:en
Short-container-title:Mol Neurobiol

Author:

Arenas Yaiza M.,Felipo Vicente^ORCID

Funder

Ministerio de Ciencia e Innovación

Conselleria de Cultura, Educación y Ciencia, Generalitat Valenciana

Ministerio de Ciencia, Innovación y Universidades

European Regional Development Funds

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Link

https://link.springer.com/content/pdf/10.1007/s12035-023-03264-4.pdf

Reference62 articles.

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2. Shawcross DL, Davies NA, Williams R, Jalan R (2004) Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol 40(2):247–254. https://doi.org/10.1016/j.jhep.2003.10.016

3. Felipo V, Urios A, Montesinos E, Molina I, Garcia-Torres ML, Civera M, Olmo JA, Ortega J et al (2012) Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy. Metab Brain Dis 27(1):51–58. https://doi.org/10.1007/s11011-011-9269-3

4. Balzano T, Dadsetan S, Forteza J, Cabrera-Pastor A, Taoro-Gonzalez L, Malaguarnera M, Gil-Perotin S, Cubas-Nuñez L et al (2020) Chronic hyperammonemia induces peripheral inflammation that leads to cognitive impairment in rats: Reversed by anti-TNFα treatment. J Hepatol 73(3):582–592. https://doi.org/10.1016/j.jhep.2019.01.008

5. Hernández-Rabaza V, Cabrera-Pastor A, Taoro-González L, Malaguarnera M, Agustí A, Llansola M, Felipo V (2016) Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane. J Neuroinflammation 13:41. https://doi.org/10.1186/s12974-016-0505-y

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