The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates

Author:

Riad Aladdin,Lengyel-Zhand Zsofia,Zeng Chenbo,Weng Chi-Chang,Lee Virginia M.-Y.,Trojanowski John Q.,Mach Robert H.ORCID

Funder

National Institute on Drug Abuse

Michael J. Fox Foundation for Parkinson's Research

Publisher

Springer Science and Business Media LLC

Subject

Neuroscience (miscellaneous),Cellular and Molecular Neuroscience,Neurology

Reference49 articles.

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2. Mach RH, Zeng C, Hawkins WG (2013) The sigma2 receptor: a novel protein for the imaging and treatment of cancer. J Med Chem 56:7137–7160. https://doi.org/10.1021/jm301545c

3. Walker JM, Bowen WD, Walker FO, Matsumoto RR, De Costa B, Rice KC (1990) Sigma receptors: biology and function. Pharmacol Rev 42:355–402

4. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE (1976) The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J Pharmacol Exp Ther 197:517–532

5. Leonard BE (2004) Sigma receptors and sigma ligands: background to a pharmacological enigma. Pharmacopsychiatry 37(Suppl 3):S166–S170. https://doi.org/10.1055/s-2004-832674

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