Author:
Merz Sarah,Kleger Alexander
Abstract
AbstractHuman pluripotent stem cells can be differentiated into the pancreatic lineage, providing a human pancreas model to study diseases and development. We improved the differentiation protocol to generate pancreatic progenitors, the common ancestor of the endocrine and exocrine pancreas. We classified the glycoprotein-2 high-expressing subpopulation as truly multipotent, thereby making it particularly suitable to engineer acinar cells. Its capability of developing simultaneously into endocrine, ductal and acinar lineages qualifies it as a useful tool for pancreatic disease modelling.
Publisher
Springer Science and Business Media LLC
Subject
Molecular Biology,Biotechnology
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