Human pancreas development-Reference-Cited by-同舟云学术

Human pancreas development

Published:2015-09-15 Issue:18 Volume:142 Page:3126-3137
ISSN:1477-9129
Container-title:Development
language:en
Short-container-title:

Author:

Jennings Rachel E.¹²,Berry Andrew A.¹,Strutt James P.¹,Gerrard David T.¹³,Hanley Neil A.¹²

Affiliation:

1. Centre for Endocrinology and Diabetes, Institute of Human Development, Faculty of Medical & Human Sciences, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK

2. Endocrinology Department, Central Manchester University Hospitals NHS Foundation Trust, Grafton St, Manchester M13 9WU, UK

3. Bioinformatics Unit, Faculty of Life Science, Manchester Academic Health Science Centre, University of Manchester, Oxford Rd, Manchester M13 9PT, UK

Abstract

A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

Publisher

The Company of Biologists

Subject

Developmental Biology,Molecular Biology

Link

http://journals.biologists.com/dev/article-pdf/142/18/3126/1838533/dev120063.pdf

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