Hypocretin Ligand Deficiency in Narcolepsy: Recent Basic and Clinical Insights
Author:
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Neuroscience
Link
http://link.springer.com/content/pdf/10.1007/s11910-010-0100-z.pdf
Reference53 articles.
1. Nishino S, Kanbayashi T: Symptomatic narcolepsy, cataplexy, and hypersomnia, and their implications in the hypothalamic hypocretin/orexin system. Sleep Med Rev 2005, 9:269–310.
2. • Nishino S: Clinical and neurobiological aspects of narcolepsy. Sleep Med 2007, 8:373–399. The author examines the centrality of hypocretin neurotransmission impairment to the pathophysiologic mechanism in narcolepsy and the potential of ligand replacement as a relevant therapeutic option in view of the results of recent animal studies.
3. Mignot E, Lammers GJ, Ripley B, et al.: The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002, 59:1553–1562.
4. Nishino S: The hypocretin/orexin system in health and disease. Bio Psychiatry 2003, 54:87–95.
5. Nishino S, Mignot E: Pharmacological aspects of human and canine narcolepsy. Prog Neurobiol 1997, 52:27–78.
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