Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation-Reference-Cited by-同舟云学术

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Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation

Published:2019-03-29 Issue:6 Volume:42 Page:
ISSN:0161-8105
Container-title:Sleep
language:en
Short-container-title:

Author:

Beuckmann Carsten Theodor¹,Ueno Takashi²^ORCID,Nakagawa Makoto¹,Suzuki Michiyuki³,Akasofu Shigeru¹

Affiliation:

1. Neurology Business Group, Discovery, Eisai Co., Ltd., Tsukuba, Japan

2. Drug Metabolism and Pharmacokinetics, Eisai Co., Ltd., Tsukuba, Japan

3. Pharmaceutical Regulatory Affairs Department, Marketing Authorization Group, EA Pharma Co., Ltd., Tokyo, Japan

Funder

Eisai Co., Ltd

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Clinical Neurology

Link

http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz076/28474442/zsz076.pdf

Reference70 articles.

1. The direct and indirect costs of untreated insomnia in adults in the United States;Ozminkowski;Sleep.,2007

2. Insomnia and the performance of US workers: results from the America Insomnia Survey;Kessler;Sleep.,2011

3. Orexin receptor antagonists as therapeutic agents for insomnia;Equihua;Front Pharmacol.,2013

4. The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions;Inutsuka;Front Endocrinol (Lausanne).,2013

5. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior;Sakurai;Cell.,1998

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1. Orexin increases the neuronal excitability of several brain areas associated with maintaining of arousal;Journal of Neurochemistry;2024-08-02

2. Sleep, inflammation, and hemodynamics in rodent models of traumatic brain injury;Frontiers in Neuroscience;2024-02-15

3. Resting phase-administration of lemborexant ameliorates sleep and glucose tolerance in type 2 diabetic mice;European Journal of Pharmacology;2023-12

4. Abuse potential assessment of the dual orexin receptor antagonist daridorexant in rats;Journal of Psychopharmacology;2023-12

5. Efficacy and safety of lemborexant in midlife women with insomnia disorder;Menopause;2023-06-20

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