Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial-Reference-Cited by-同舟云学术

Comparison of the Systemic and Local Pharmacokinetics of Clonidine Mucoadhesive Buccal Tablets with Reference Clonidine Oral Tablets in Healthy Volunteers: An Open-Label Randomised Cross-Over Trial

Published:2017-07-19 Issue:8 Volume:34 Page:2022-2032
ISSN:0741-238X
Container-title:Advances in Therapy
language:en
Short-container-title:Adv Ther

Author:

Vasseur Bérangère,Dufour Alain,Houdas Laetitia,Goodwin Helen,Harries Kathryn,Emul Neslihan Yesiltas,Hutchings Simon^ORCID

Funder

Onxeo SA

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Medicine

Link

http://link.springer.com/article/10.1007/s12325-017-0585-9/fulltext.html

Reference17 articles.

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3. Lalla R, Bowen J, Barasch A, Elting L, Epstein J, Keefe D, McGuire D, Migliorati C, Nicolatou-Galitis O, Peterson D, Raber-Durlacher J, Sonis S, Elad S. MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2014;121(8):1453–61.

4. Lavand’homme P, Eisenach J. Perioperative administration of the alpha2-adrenoceptor agonist clonidine at the site of nerve injury reduces the development of mechanical hypersensitivity and modulates local cytokine expression. Pain. 2003;105(1–2):247–54.

5. Romero-Sandoval A, Eisenach J. Clonidine reduces hypersensitivity and alters the balance of pro- and anti-inflammatory leukocytes after local injection at the site of inflammatory neuritis. Brain Behav Immun. 2007;21(5):569–80.

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