Identifying Clinically Relevant Drug–Drug Interactions With Methadone and Buprenorphine: A Translational Approach to Signal Detection

Author:

Miano Todd A.12,Wang Lei3,Leonard Charles E.124ORCID,Brensinger Colleen M.12,Acton Emily K.12ORCID,Dawwas Ghadeer K.12ORCID,Bilker Warren B.125ORCID,Soprano Samantha E.12,Nguyen Thanh Phuong Pham16ORCID,Woody George5,Yu Elmer5,Neuman Mark7,Li Lang3,Hennessy Sean1238ORCID

Affiliation:

1. Center for Pharmacoepidemiology Research and Training, Center for Clinical Epidemiology and Biostatistics University of Pennsylvania Philadelphia Pennsylvania USA

2. Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

3. Department of Biomedical Informatics, College of Medicine The Ohio State University Columbus Ohio USA

4. Leonard Davis Institute of Health Economics University of Pennsylvania Philadelphia Pennsylvania USA

5. Department of Psychiatry, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

6. Translational Center of Excellence for Neuroepidemiology and Neurology Outcomes Research, Department of Neurology, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

7. Department of Anesthesiology and Critical Care, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

8. Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania USA

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference51 articles.

1. The ASAM National Practice Guideline for the Treatment of Opioid Use Disorder – 2020.Focused Update. Accessed March 13 2021.

2. Substance Abuse and Mental Health Services Administration (US); Office of the Surgeon General (US).Facing addiction in America: The surgeon general's report on alcohol drugs and health. Washington (DC): US Department of Health and Human Services (2016). Accessed May 22 2021.

3. Methadone in Pain Management: A Systematic Review

4. Benefit-Risk Analysis of Buprenorphine for Pain Management

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