Rapid Characterization of Insulin Modifications and Sequence Variations by Proteinase K Digestion and UHPLC-ESI-MS
Author:
Affiliation:
1. Analytical Research and Development, Merck and Co., Inc., 07065, Rahway, NJ, USA
Publisher
American Chemical Society (ACS)
Subject
Spectroscopy,Structural Biology
Link
http://link.springer.com/article/10.1007/s13361-017-1887-5/fulltext.html
Reference18 articles.
1. Insulin analogues: an example of applied medical science
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3. Insulin glargine and its role in glycaemic management of Type 2 diabetes
4. Insulin aspart: a novel rapid-acting human insulin analogue
5. Glucose-responsive insulin activity by covalent modification with aliphatic phenylboronic acid conjugates
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2. Identification of recombinant human insulin and biosynthetic insulin analogues by multiplexed targeted unlabeled mass spectrometry of proteotypic tryptic peptides;Journal of Pharmaceutical and Biomedical Analysis;2019-08
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