Spatial Segmentation of MALDI FT-ICR MSI Data: A Powerful Tool to Explore the Head and Neck Tumor In Situ Lipidome

Author:

Krasny Lukas1,Hoffmann Franziska2,Ernst Günther2,Trede Dennis34,Alexandrov Theodore345,Havlicek Vladimir1,Guntinas-Lichius Orlando6,von Eggeling Ferdinand2678,Crecelius Anna C.89

Affiliation:

1. Institute of Microbiology, v.v.i., Videnska 1083, CZ 142 20, Prague 4, Czech Republic

2. Institute of Physical Chemistry, Friedrich Schiller University Jena, Helmholtzweg 4, 07743, Jena, Germany

3. SCiLS GmbH, Fahrenheitstraße 1, 28359, Bremen, Germany

4. Steinbeis Innovation Center SCiLS Research, Fahrenheitstraße 1, 28359, Bremen, Germany

5. Center for Industrial Mathematics, University of Bremen, Bibliothekstraße 1, 28359, Bremen, Germany

6. Department of Otorhinolaryngology, Jena University Hospital, Lessingstraße 2, 07743, Jena, Germany

7. Leibnitz Institute of Photonic Technology (IPHT), Albert-Einstein-Straße 9, 07745, Jena, Germany

8. Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, 07743, Jena, Germany

9. Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, 07743, Jena, Germany

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Reference21 articles.

1. Spengler, B., Hubert, M., Kaufmann, R.: MALDI ion imaging and biological ion imaging with a new scanning UV-laser microprobe. Proceedings of the 42nd Annual Conference on Mass Spectrometry and Allied Topics, pp. 1041, Chicago, IL (1994)

2. Molecular Imaging of Biological Samples:  Localization of Peptides and Proteins Using MALDI-TOF MS

3. Matrix-Assisted Laser Desorption Ionization Imaging Mass Spectrometry: In Situ Molecular Mapping

4. Lipid imaging by mass spectrometry – a review

5. Visualizing spatial lipid distribution in porcine lens by MALDI imaging high-resolution mass spectrometry

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