Clinical phenotyping uncovers heterogeneous associations between corticosteroid treatment and survival in critically ill COVID-19 patients

Author:

Bruse Niklas,Motos Anna,van Amstel Rombout,de Bie Eckart,Kooistra Emma J.,Jansen Aron,van Lier Dirk,Kennedy Jason,Schwarzkopf Daniel,Thomas-Rüddel Daniel,Bermejo-Martin Jesus F.,Barbe Ferran,de Keizer Nicolette F.,Bauer Michael,van der Hoeven Johannes G.,Torres Antoni,Seymour Christopher,van Vught Lonneke,Pickkers Peter,Kox MatthijsORCID

Funder

European Society of Intensive Care Medicine

ZonMw

Publisher

Springer Science and Business Media LLC

Reference30 articles.

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2. Group WHOREAfC-TW, Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, Annane D, Azevedo LCP, Berwanger O, Cavalcanti AB, Dequin PF, Du B, Emberson J, Fisher D, Giraudeau B, Gordon AC, Granholm A, Green C, Haynes R, Heming N, Higgins JPT, Horby P, Juni P, Landray MJ, Le Gouge A, Leclerc M, Lim WS, Machado FR, McArthur C, Meziani F, Moller MH, Perner A, Petersen MW, Savovic J, Tomazini B, Veiga VC, Webb S, Marshall JC (2020) Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis. JAMA 324:1330–1341

3. Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W et al (2020) Effect of hydrocortisone on mortality and organ support in patients with severe COVID-19: the REMAP-CAP COVID-19 corticosteroid domain randomized clinical trial. JAMA 324:1317–1329

4. Keller MJ, Kitsis EA, Arora S, Chen JT, Agarwal S, Ross MJ, Tomer Y, Southern W (2020) Effect of systemic glucocorticoids on mortality or mechanical ventilation in patients with COVID-19. J Hosp Med 15:489–493

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