Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study

Author:

Höcht Christian,Di Verniero Carla,Opezzo Javier A. W.,Bramuglia Guillermo F.,Taira Carlos A.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference38 articles.

1. Abboud FM (1982) The sympathetic system in hypertension. State-of-the-art review. Hypertension 4(3 Pt 2):208–225

2. Adams MA, Bobik A, Korner PI (1989) Differential development of vascular and cardiac hypertrophy in genetic hypertension. Relation to sympathetic function. Hypertension 14:191–202

3. Antonaccio MJ, High J, DeForrest JM, Sybertz E (1986) Antihypertensive effects of 12 beta adrenoceptor antagonists in conscious spontaneously hypertensive rats: relationship to changes in plasma renin activity, heart rate and sympathetic nerve function. J Pharmacol Exp Ther 238:378–387

4. Benveniste H, Huttemeier PC (1990) Microdialysis—theory and application. Prog Neurobiol 33:195–215

5. Brynne L, Karlsson MO, Paalzow LK (1998) Concentration-effect relationship of l-propranolol and metoprolol in spontaneous hypertensive rats after exercise-induced tachycardia. J Pharmacol Exp Ther 286:1152–1158

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