Pretreatment with vildagliptin boosts ischemic-postconditioning effects on cardioprotection and expression profile of genes regulating autophagy and mitochondrial fission/fusion in diabetic heart with reperfusion injury

Author:

Pirzeh Lale,Babapour Vahab,Badalzadeh RezaORCID,Panahi Negar

Funder

93.5-4.8

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology,General Medicine

Reference33 articles.

1. Apaijai N, Pintana H, Chattipakorn SC, Chattipakorn N (2013) Effects of vildagliptin versus sitagliptin, on cardiac function, heart rate variability and mitochondrial function in obese insulin-resistant rats. Br J Pharmacol 169(5):1048–1057. https://doi.org/10.1111/bph.12176

2. Apaijai N1, Chinda K, Palee S, Chattipakorn S, Chattipakorn N (2014) Combined vildagliptin and metformin exert better cardioprotection than monotherapy against ischemia-reperfusion injury in obese-insulin resistant rats. PLoS One 9(7):e102374. https://doi.org/10.1371/journal.pone.0102374

3. Badalzadeh R, Azimi A, Alihemmati A, Yousefi B (2017a) Chronic type-I diabetes could not impede the anti-inflammatory and antiapoptotic effects of combined postconditioning with ischemia and cyclosporine a in myocardial reperfusion injury. J Physiol Biochem 73(1):111–120. https://doi.org/10.1007/s13105-016-0530-4

4. Badalzadeh R, Tabatabaei SM, Mohammadi M, Khaki A, Mohammadnezhad D (2017b) Combined postconditioning with ischemia and cyclosporine-A restore oxidative stress and histopathological changes in reperfusion injury of diabetic myocardium. Iran J Basic Med Sci 20(10):1079–1087. https://doi.org/10.22038/IJBMS.2017.9444

5. Bayrami G, Karimi P, Agha-Hosseini F, Feyzizadeh S, Badalzadeh R (2018) Effect of ischemic postconditioning on myocardial function and infarct size following reperfusion injury in diabetic rats pretreated with vildagliptin. J Cardiovasc Pharmacol Ther 23(2):174–183. https://doi.org/10.1177/1074248417729881

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