Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges

Author:

Jossen ValentinORCID,van den Bos Christian,Eibl Regine,Eibl Dieter

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,General Medicine,Biotechnology

Reference103 articles.

1. Abdelrazik H, Spaggiari GM, Chiossone L, Mretta L (2011) Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function. Eur J Immunol 41:3281–3290

2. Abraham E, Gupta S, Jung S, McAfee E (2017) Bioreactor for scale-up: process control. In: Mesenchymal stem cells. pp 139–177

3. Advice R (2011) The Innovation Office at the Paul-Ehrlich-Institut

4. Agency EM (2007) European Medicines Agency—advanced therapy development—certification procedures for micro-, small- and medium-sized enterprises (SMEs). http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/general/general_content_000300.jsp&mid=WC0b01ac058095e6d5

5. Aggarwal S, Pittenger MF (2005) Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815–1822. https://doi.org/10.1182/blood-2004-04-1559

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