Old Friends with Unexploited Perspectives: Current Advances in Mesenchymal Stem Cell-Based Therapies in Asthma-Reference-Cited by-同舟云学术

Old Friends with Unexploited Perspectives: Current Advances in Mesenchymal Stem Cell-Based Therapies in Asthma

Published:2021-03-01 Issue:4 Volume:17 Page:1323-1342
ISSN:2629-3269
Container-title:Stem Cell Reviews and Reports
language:en
Short-container-title:Stem Cell Rev and Rep

Author:

Tynecka Marlena,Moniuszko Marcin,Eljaszewicz Andrzej^ORCID

Abstract

AbstractMesenchymal stem cells (MSCs) have a great regenerative and immunomodulatory potential that was successfully tested in numerous pre-clinical and clinical studies of various degenerative, hematological and inflammatory disorders. Over the last few decades, substantial immunoregulatory effects of MSC treatment were widely observed in different experimental models of asthma. Therefore, it is tempting to speculate that stem cell-based treatment could become an attractive means to better suppress asthmatic airway inflammation, especially in subjects resistant to currently available anti-inflammatory therapies. In this review, we discuss mechanisms accounting for potent immunosuppressive properties of MSCs and the rationale for their use in asthma. We describe in detail an intriguing interplay between MSCs and other crucial players in the immune system as well as lung microenvironment. Finally, we reveal the potential of MSCs in maintaining airway epithelial integrity and alleviating lung remodeling. Graphical abstract

Funder

Narodowe Centrum Nauki

Narodowe Centrum Badań i Rozwoju

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1007/s12015-021-10137-7.pdf

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