Anxiety and depression in Charcot-Marie-Tooth disease: data from the Italian CMT national registry
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Published:2022-09-16
Issue:1
Volume:270
Page:394-401
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ISSN:0340-5354
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Container-title:Journal of Neurology
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language:en
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Short-container-title:J Neurol
Author:
Bellofatto MartaORCID, Bertini Alessandro, Tramacere Irene, Manganelli Fiore, Fabrizi Gian Maria, Schenone Angelo, Santoro Lucio, Cavallaro Tiziana, Grandis Marina, Previtali Stefano C., Allegri Isabella, Padua Luca, Pazzaglia Costanza, Calabrese Daniela, Saveri Paola, Quattrone Aldo, Valentino Paola, Tozza Stefano, Gentile Luca, Russo Massimo, Mazzeo Anna, Vita Giuseppe, Piacentini Sylvie, Pisciotta Chiara, Pareyson DavideORCID, Schirinzi Giulia, Montesano Maria, Nuzzo Sara, Oggiano Francesca, Gemelli Chiara, Scarlato Marina, Spina Emanuele, Longo Maria,
Abstract
Abstract
Background
There is little information about neuropsychiatric comorbidities in Charcot-Marie-Tooth disease (CMT). We assessed frequency of anxiety, depression, and general distress in CMT.
Methods
We administered online the Hospital Anxiety-Depression Scale (HADS) to CMT patients of the Italian registry and controls. HADS-A and HADS-D scores ≥ 11 defined the presence of anxiety/depression and HADS total score (HADS-T) ≥ 22 of general distress. We analysed correlation with disease severity and clinical characteristics, use of anxiolytics/antidepressants and analgesic/anti-inflammatory drugs.
Results
We collected data from 252 CMT patients (137 females) and 56 controls. CMT patient scores for anxiety (mean ± standard deviation, 6.7 ± 4.8), depression (4.5 ± 4.0), and general distress (11.5 ± 8.1) did not differ from controls and the Italian population. However, compared to controls, the percentages of subjects with depression (10% vs 2%) and general distress (14% vs 4%) were significantly higher in CMT patients. We found no association between HADS scores and disease duration or CMT type. Patients with general distress showed more severe disease and higher rate of positive sensory symptoms. Depressed patients also had more severe disease. Nineteen percent of CMT patients took antidepressants/anxiolytics (12% daily) and 70% analgesic/anti-inflammatory drugs. Patients with anxiety, depression, and distress reported higher consumption of anxiolytics/antidepressants. About 50% of patients with depression and/or general distress did not receive any specific pharmacological treatment.
Conclusions
An appreciable proportion of CMT patients shows general distress and depression. Both correlated with disease severity and consumption of antidepressants/anxiolytics, suggesting that the disease itself is contributing to general distress and depression.
Funder
Fondazione Telethon
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology
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