Daytime sleepiness and sleep quality in Charcot–Marie–Tooth disease
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Published:2023-08-04
Issue:11
Volume:270
Page:5561-5568
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ISSN:0340-5354
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Container-title:Journal of Neurology
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language:en
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Short-container-title:J Neurol
Author:
Bellofatto Marta, Gentile Luca, Bertini Alessandro, Tramacere Irene, Manganelli Fiore, Fabrizi Gian Maria, Schenone Angelo, Santoro Lucio, Cavallaro Tiziana, Grandis Marina, Previtali Stefano C., Scarlato Marina, Allegri Isabella, Padua Luca, Pazzaglia Costanza, Villani Flavio, Cavalca Eleonora, Saveri Paola, Quattrone Aldo, Valentino Paola, Tozza Stefano, Russo Massimo, Mazzeo Anna, Vita Giuseppe, Piacentini Sylvie, Didato Giuseppe, Pisciotta Chiara, Pareyson DavideORCID, Schirinzi Giulia, Montesano Maria, Nuzzo Sara, Oggiano Francesca, Calabrese Daniela, Gemelli Chiara, Falzone Yuri, Spina Emanuele, Longo Maria, Occhipinti Giuseppe, Iabichella Giacomo, Barone Stefania,
Abstract
Abstract
Background
Sleep abnormalities have been reported in Charcot–Marie–Tooth disease (CMT), but data are scanty. We investigated their presence and correlation in a large CMT patients’ series.
Methods
Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI) were administered to CMT patients of the Italian registry and controls. ESS score > 10 indicated abnormal daytime somnolence, PSQI score > 5 bad sleep quality. We analyzed correlation with disease severity and characteristics, Hospital Anxiety and Depression Scale (HADS), Modified Fatigue Impact Scale (MFIS), Body Mass Index, drug use.
Results
ESS and PSQI questionnaires were filled by 257 and 253 CMT patients, respectively, and 58 controls. Median PSQI score was higher in CMT patients than controls (6 vs 4, p = 0.006), with no difference for ESS score. Abnormal somnolence and poor sleep quality occurred in 23% and 56% of patients; such patients had more frequently anxiety/depression, abnormal fatigue, and positive sensory symptoms than those with normal ESS/PSQI. Moreover, patients with PSQI score > 5 had more severe disease (median CMT Examination Score, CMTES, 8 vs 6, p = 0.006) and more frequent use of anxiolytic/antidepressant drugs (29% vs 7%, p < 0.001).
Conclusions
Bad sleep quality and daytime sleepiness are frequent in CMT and correlated with anxiety, depression and fatigue, confirming that different components affect sleep. Sleep disorders, such as sleep apnea and restless leg syndrome, not specifically investigated here, are other factors known to impact on sleep quality and somnolence. CMT patients’ management must include sleep behavior assessment and evaluation of its correlated factors, including general distress and fatigue.
Funder
Fondazione Telethon
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),Neurology
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