Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver-Reference-Cited by-同舟云学术

Application of the axial dispersion model of hepatic drug elimination to the kinetics of diazepam in the isolated perfused rat liver

Published:1992-04 Issue:2 Volume:20 Page:171-193
ISSN:0090-466X
Container-title:Journal of Pharmacokinetics and Biopharmaceutics
language:en
Short-container-title:Journal of Pharmacokinetics and Biopharmaceutics

Author:

Diaz-Garcia Juan M.,Evans Allan M.,Rowland Malcolm

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/BF01071000.pdf

Reference31 articles.

1. G. R. Wilkinson. Clearance concepts in pharmacology.Pharm. Rev. 39:1–47 (1987).

2. K. S. Pang and M. Rowland. Hepatic clearance of drugs. I. Theoretical considerations of a “well stirred” model and a “parallel-tube” model. Influence of hepatic blood flow, plasma and blood cell binding and the hepatocellular enzymatic activity on hepatic drug clearance.J. Pharmacokin. Biopharm. 5:625–653 (1977).

3. M. S. Roberts and M. Rowland. A dispersion model of hepatic elimination. 1. Formulation of the model and bolus considerations.J. Pharmacokin. Biopharm. 14:227–260 (1986).

4. L. Bass, P. Robinson, and A. J. Bracken. Hepatic elimination of flowing substances: The distributed model.J. Theoret. Biol. 72:161–184 (1978).

5. E. L. Forker and B. Luxon. Hepatic transport kinetics and plasma disappearance curves: Distributed modelling versus conventional approach.Am. J. Physiol. 235:E648-E660, (1978).

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