Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection
Author:
Publisher
Springer Science and Business Media LLC
Subject
Infectious Diseases,Virology
Link
http://link.springer.com/content/pdf/10.1007/s11904-006-0002-5.pdf
Reference74 articles.
1. Rosenberg ES, Billingsley JM, Caliendo AM, et al.: Vigorous HIV-1-specific CD4+T cell responses associated with control of viremia. Science 1997, 278:1447–1450.
2. Kalams SA, Walker BD: The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998, 188:2199–2204.
3. Migueles SA, Connors M: The role of CD4(+) and CD8(+) T cells in controlling HIV infection. Curr Infect Dis Rep 2002, 4:461–467.
4. Veazey RS, DeMaria M, Chalifoux LV, et al.: Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 1998, 280:427–431. This is the first definitive demonstration of depletion of CD4+ T cells from GALT in macaques with SIV infection.
5. Mattapallil JJ, Douek DC, Hill B, et al.: Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV Infection. Nature 2005, 434:1093–1097. This is a demonstration of possible complete depletion of CD4+ memory cells from all lymphoid tissue by SIV infection in macaques. It also demonstrates that a larger population of memory cells may carry CCR5.
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