Immune Reconstitution in Chronic Lymphocytic Leukemia
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Oncology,Hematology
Link
http://link.springer.com/content/pdf/10.1007/s11899-011-0106-x.pdf
Reference79 articles.
1. • Eichhorst BF, Busch R, Stilgenbauer S, et al.: First-line therapy with fludarabine compared with chlorambucil does not result in a major benefit for elderly patients with advanced chronic lymphocytic leukemia. Blood 2009, 114:3382–91. This important clinical trial highlights the challenges of successfully treating elderly patients with CLL, emphasizing the need for novel noncytotoxic therapies for this disease.
2. •• Hallek M, Fischer K, Fingerle-Rowson G, et al.: Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010, 376:1164–74. This phase 3 trial demonstrates the survival advantage of the addition of rituximab to fludarabine and cyclophosphamide, and underpins the current standard of care in CLL.
3. Dunn GP, Bruce AT, Ikeda H, et al. Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3:991–8.
4. Catovsky D, Miliani E, Okos A, et al. Clinical significance of T-cells in chronic lymphocytic leukaemia. Lancet. 1974;2:751–2.
5. Platsoucas CD, Galinski M, Kempin S, et al. Abnormal T lymphocyte subpopulations in patients with B cell chronic lymphocytic leukemia: an analysis by monoclonal antibodies. J Immunol. 1982;129:2305–12.
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