H2AX phosphorylation regulated by p38 is involved in Bim expression and apoptosis in chronic myelogenous leukemia cells induced by imatinib-Reference-Cited by-同舟云学术

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H2AX phosphorylation regulated by p38 is involved in Bim expression and apoptosis in chronic myelogenous leukemia cells induced by imatinib

Published:2014-05-15 Issue:8 Volume:19 Page:1281-1292
ISSN:1360-8185
Container-title:Apoptosis
language:en
Short-container-title:Apoptosis

Author:

Dong Yaqiong,Xiong Min,Duan Lianning,Liu Ze,Niu Tianhui,Luo Yuan,Wu Xinpin,Xu Chengshan,Lu Chengrong

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Biochemistry (medical),Cell Biology,Clinical Biochemistry,Pharmaceutical Science,Pharmacology

Link

http://link.springer.com/content/pdf/10.1007/s10495-014-0997-9.pdf

Reference35 articles.

1. Goldman JM, Melo JV (2001) Targeting the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med 344:1084–1086

2. Goldman JM, Melo JV (2003) Chronic myeloid leukemia–advances in biology and new approaches to treatment. N Engl J Med 349:1451–1464

3. Brauer KM, Werth D, von Schwarzenberg K, Bringmann A, Kanz L, Grunebach F (2007) BCR-ABL activity is critical for the immunogenicity of chronic myelogenous leukemia cells. Cancer Res 67:5489–5497

4. Zhang YJ, Lu CR, Cao Y, Luo Y, Bao RF, Yan S et al (2013) Imatinib induces H2AX phosphorylation and apoptosis in chronic myelogenous leukemia cells in vitro via caspase-3/Mst1 pathway. Acta Pharmacol Sin 33:551–557

5. Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K et al (2009) Activation of the p38 Map kinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma 50:2017–2029

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