Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer-Reference-Cited by-同舟云学术

Phase I dose-escalation study of F14512, a polyamine-vectorized topoisomerase II inhibitor, in patients with platinum-refractory or resistant ovarian cancer

Published:2018-12-14 Issue:4 Volume:37 Page:693-701
ISSN:0167-6997
Container-title:Investigational New Drugs
language:en
Short-container-title:Invest New Drugs

Author:

Leary Alexandra,Le Tourneau Christophe,Varga Andrea,Sablin Marie-Paule,Gomez-Roca Carlos,Guilbaud Nicolas,Petain Aurelie,Pavlyuk Mariya,Delord Jean-Pierre^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Link

http://link.springer.com/content/pdf/10.1007/s10637-018-0688-4.pdf

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4. Barret JM, Kruczynski A, Vispé S, Annereau JP, Brel V, Guminski Y et al (2008) F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system. Cancer Res 68:9845–9853

5. Ballot C, Jendoubi M, Kluza JJ, Jonneaux AAA, Laine W, Formstecher P, Bailly C, Marchetti P (2012) Regulation by survivin of cancer cell death induced by F14512, a polyamine-containing inhibitor of DNA topoisomerase II. Apoptosis 17:364–376

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