Abstract
c-MYC and its paralogues MYCN and MYCL are among the most frequently amplified and/or overexpressed oncoproteins in ovarian cancer. c-MYC plays a key role in promoting ovarian cancer initiation and progression. The polyamine pathway is a bona fide target of c-MYC signaling, and polyamine metabolism is strongly intertwined with ovarian malignancy. Targeting of the polyamine pathway via small molecule inhibitors has garnered considerable attention as a therapeutic strategy for ovarian cancer. Herein, we discuss the involvement of c-MYC signaling and that of its paralogues in promoting ovarian cancer tumorigenesis. We highlight the potential of targeting c-MYC-driven polyamine metabolism for the treatment of ovarian cancers and the utility of polyamine signatures in biofluids for early detection applications.
Reference229 articles.
1. Cancer statistics, 2022;Siegel;CA Cancer J. Clin.,2022
2. Reflecting on 25 years with MYC;Meyer;Nat. Rev. Cancer,2008
3. MYC on the path to cancer;Dang;Cell,2012
4. Kalkat, M., De Melo, J., Hickman, K.A., Lourenco, C., Redel, C., Resetca, D., Tamachi, A., Tu, W.B., and Penn, L.Z. (2017). MYC Deregulation in Primary Human Cancers. Genes, 8.
5. Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas;Schaub;Cell Syst.,2018
Cited by
4 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献