Phase Ia dose escalation study of OBP-801, a cyclic depsipeptide class I histone deacetylase inhibitor, in patients with advanced solid tumors
Author:
Funder
oncolys
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Pharmacology,Oncology
Link
https://link.springer.com/content/pdf/10.1007/s10637-021-01180-9.pdf
Reference10 articles.
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2. Kim HJ, Bae SC (2011) Histone deacetylase inhibitors: molecular mechanisms of action and clinical trials as anti-cancer drugs. Am J Transl Res 3(2):166–179
3. Marks PA, Richon VM, Miller T, Kelly WK (2004) Histone deacetylase inhibitors. Adv Cancer Res 91: 137–168. https://doi.org/10.1016/S0065-230X(04)91004-4
4. Roth SY,Allis CD (1996) Histone acetylation and chromatin assembly: a single escort, multiple dances? Cell 87(1): 5–8. https://doi.org/10.1016/s0092-8674(00)81316-1
5. Spange S, Wagner T, Heinzel T, Kramer OH (2009) Acetylation of non-histone proteins modulates cellular signalling at multiple levels. Int J Biochem Cell Biol 41(1): 185–198. https://doi.org/10.1016/j.biocel.2008.08.027
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