A dose-finding, pharmacokinetic and pharmacodynamic study of a novel schedule of flavopiridol in patients with advanced solid tumors

Author:

Ramaswamy Bhuvaneswari,Phelps Mitch A.,Baiocchi Robert,Bekaii-Saab Tanios,Ni Wenjun,Lai Ju-Ping,Wolfson Anna,Lustberg Mark E.,Wei Lai,Wilkins Deidre,Campbell Angela,Arbogast Daria,Doyle Austin,Byrd John C.,Grever Michael R.,Shah Manisha H.

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Pharmacology,Oncology

Reference41 articles.

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2. Lam LT, Pickeral OK, Peng AC et al (2001) Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol. Genome Biol 2: RESEARCH0041

3. Senderowicz AM (1999) Flavopiridol: the first cyclin-dependent kinase inhibitor in human clinical trials. Investig New Drugs 17:313–320

4. Gojo I, Zhang B, Fenton RG (2002) The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res 8:3527–3538

5. Kitada S, Zapata JM, Andreeff M, Reed JC (2000) Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 96:393–397

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