Immunoparesis defined by heavy/light chain pair suppression in smoldering multiple myeloma shows initial isotype specificity and involves other isotypes in advanced disease

Author:

Isola Ignacio,Moreno David F.,Moga Esther,Mena Mari-Pau,Tovar Natalia,Rodríguez-Lobato Luis Gerardo,Oliver-Caldés Aina,Salgado M. Carmen,Brasó-Maristany Fara,Yagüe Jordi,Cibeira M. Teresa,Prat Aleix,Rosiñol Laura,Bladé Joan,Fernández de Larrea Carlos

Funder

Instituto de Salud Carlos III

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference35 articles.

1. Kapoor P, Rajkumar SV (2019) Smoldering multiple myeloma: to treat or not to treat. Cancer J 25(1):65–71. https://doi.org/10.1097/PPO.0000000000000350

2. Dispenzieri A, Kyle RA, Katzmann JA, Therneau TM, Larson D, Benson J, Clark RJ, Melton LJ 3rd, Gertz MA, Kumar SK, Fonseca R, Jelinek DF, Rajkumar SV (2008) Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma. Blood 111(2):785–789. https://doi.org/10.1182/blood-2007-08-108357

3. Pérez-Persona E, Vidriales MB, Mateo G, García-Sanz R, Mateos MV, de Coca AG, Galende J, Martín-Nuñez G, Alonso JM, de Las HN, Hernández JM, Martín A, López-Berges C, Orfao A, San Miguel JF (2007) New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells. Blood 110(7):2586–2592. https://doi.org/10.1182/blood-2007-05-088443

4. Mateos MV, Kumar S, Dimopoulos MA, González-Calle V, Kastritis E, Hajek R, De Larrea CF, Morgan GJ, Merlini G, Goldschmidt H, Geraldes C, Gozzetti A, Kyriakou C, Garderet L, Hansson M, Zamagni E, Fantl D, Leleu X, Kim BS, Esteves G, Ludwig H, Usmani S, Min CK, Qi M, Ukropec J, Weiss BM, Rajkumar SV, Durie BGM, San-Miguel J (2020) International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM). Blood Cancer J 10(10):102. https://doi.org/10.1038/s41408-020-00366-3

5. Zamagni E, Nanni C, Gay F, Pezzi A, Patriarca F, Bellò M, Rambaldi I, Tacchetti P, Hillengass J, Gamberi B, Pantani L, Magarotto V, Versari A, Offidani M, Zannetti B, Carobolante F, Balma M, Musto P, Rensi M, Mancuso K, Dimitrakopoulou-Strauss A, Chauviè S, Rocchi S, Fard N, Marzocchi G, Storto G, Ghedini P, Palumbo A, Fanti S, Cavo M (2016) 18F-FDG PET/CT focal, but not osteolytic, lesions predict the progression of smoldering myeloma to active disease. Leukemia 30(2):417–422. https://doi.org/10.1038/leu.2015.291

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