Normal karyotype acute myeloid leukemia patients with CEBPA double mutation have a favorable prognosis but no survival benefit from allogeneic stem cell transplant

Author:

Ahn Jae-Sook,Kim Jae-Young,Kim Hyeoung-Joon,Kim Yeo-Kyeoung,Lee Seung-Shin,Jung Sung-Hoon,Yang Deok-Hwan,Lee Je-Jung,Kim Nan Young,Choi Seung Hyun,Minden Mark D.,Jung Chul Won,Jang Jun-Ho,Kim Hee Je,Moon Joon Ho,Sohn Sang Kyun,Won Jong-Ho,Kim Sung-Hyun,Kim Dennis Dong Hwan

Funder

National Project for Personalized Genomic Medicine, Ministry for Health & Welfare, Republic of Korea

Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF), funded by the Ministry of Education, Science, and Technology (MEST)

Research Institute of Medical Sciences

Publisher

Springer Science and Business Media LLC

Subject

Hematology,General Medicine

Reference25 articles.

1. Koschmieder S, Halmos B, Levantini E, Tenen DG (2009) Dysregulation of the C/EBPalpha differentiation pathway in human cancer. J Clin Oncol : Off J Am Soc Clin Oncol 27(4):619–628. doi: 10.1200/JCO.2008.17.9812

2. Martelli MP, Sportoletti P, Tiacci E, Martelli MF, Falini B (2013) Mutational landscape of AML with normal cytogenetics: biological and clinical implications. Blood Rev 27(1):13–22. doi: 10.1016/j.blre.2012.11.001

3. Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen DG (2001) Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nat Genet 27(3):263–270. doi: 10.1038/85820

4. Schlenk RF, Taskesen E, van Norden Y, Krauter J, Ganser A, Bullinger L, Gaidzik VI, Paschka P, Corbacioglu A, Gohring G, Kundgen A, Held G, Gotze K, Vellenga E, Kuball J, Schanz U, Passweg J, Pabst T, Maertens J, Ossenkoppele GJ, Delwel R, Dohner H, Cornelissen JJ, Dohner K, Lowenberg B (2013) The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA. Blood 122(9):1576–1582. doi: 10.1182/blood-2013-05-503847

5. Green CL, Koo KK, Hills RK, Burnett AK, Linch DC, Gale RE (2010) Prognostic significance of CEBPA mutations in a large cohort of younger adult patients with acute myeloid leukemia: impact of double CEBPA mutations and the interaction with FLT3 and NPM1 mutations. J Clin Oncol : Off J Am Soc Clin Oncol 28(16):2739–2747. doi: 10.1200/JCO.2009.26.2501

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