Early and late renal function changes with spironolactone in patients at risk of developing heart failure: findings from the HOMAGE trial

Author:

Ferreira João PedroORCID,Cleland John G. F.,Girerd Nicolas,Pellicori Pierpaolo,Hazebroek Mark R.,Verdonschot Job,Collier Timothy J.,Petutschnigg Johannes,Clark Andrew L.,Staessen Jan A.,Heymans Stephane,Zannad Faiez,Rossignol Patrick

Funder

FP7 Science in Society

Publisher

Springer Science and Business Media LLC

Subject

Cardiology and Cardiovascular Medicine,General Medicine

Reference10 articles.

1. Rossignol P, Dobre D, McMurray JJ, Swedberg K, Krum H, van Veldhuisen DJ, Shi H, Messig M, Vincent J, Girerd N et al (2014) Incidence, determinants, and prognostic significance of hyperkalemia and worsening renal function in patients with heart failure receiving the mineralocorticoid receptor antagonist eplerenone or placebo in addition to optimal medical therapy: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF). Circ Heart Fail 7:51–58. https://doi.org/10.1161/circheartfailure.113.000792

2. Vardeny O, Wu DH, Desai A, Rossignol P, Zannad F, Pitt B, Solomon SD (2012) Influence of baseline and worsening renal function on efficacy of spironolactone in patients With severe heart failure: insights from RALES (Randomized Aldactone Evaluation Study). J Am Coll Cardiol 60:2082–2089. https://doi.org/10.1016/j.jacc.2012.07.048

3. Beldhuis IE, Myhre PL, Bristow M, Claggett B, Damman K, Fang JC, Fleg JL, McKinlay S, Lewis EF, O’Meara E et al (2021) Spironolactone in patients with heart failure, preserved ejection fraction, and worsening renal function. J Am Coll Cardiol 77:1211–1221. https://doi.org/10.1016/j.jacc.2020.12.057

4. Rossignol P, Hernandez AF, Solomon SD, Zannad F (2019) Heart failure drug treatment. Lancet 393:1034–1044. https://doi.org/10.1016/s0140-6736(18)31808-7

5. Cleland JGF, Ferreira JP, Mariottoni B, Pellicori P, Cuthbert J, Verdonschot JAJ, Petutschnigg J, Ahmed FZ, Cosmi F, Brunner La Rocca HP et al (2020) The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart “OMics” in AGEing (HOMAGE) randomized clinical trial. Eur Heart J. https://doi.org/10.1093/eurheartj/ehaa758

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