Enzymatic synthesis of cefazolin using immobilized recombinant cephalosporin-acid synthetase as the biocatalyst

Author:

Wang Lu,Sklyarenko A. V.,Li Duanhua,Sidorenko A. I.,Zhao Chen,Li Jinjun,Yarotsky S. V.

Funder

Science and Technology Bureau, Chengdu Municipal Government Project

Science and Technology Department of Sichuan Province Project

Publisher

Springer Science and Business Media LLC

Subject

General Medicine,Bioengineering,Biotechnology

Reference21 articles.

1. Sklyarenko AV, Eldarov MA, Kurochkina VB, Yarotsky SV (2015) Enzymatic synthesis of cephalosporin-acids. Review Appl Biochem Microbiol 51(6):627–640

2. Kurochkina VB, Nys PS (1999) Enzymatic synthesis of beta-lactam antibiotics. I. Cefazolin. Antibiotiki i Chiomiotherapi (Russia) 44(5):12–16

3. Kurochkina VB, Nys PS (2002) Kinetic and thermodynamic approach to design the processes for enzymatic synthesis of beta-lactams. Biocatal Biotransform 20:35–41

4. Volpato G, Rodriges RC, Fernandez-Lafuente R (2010) Use of enzymes in production of semi-synthetic penicillins and cephalosporins: drawbacks and perspectives. Curr Med Chem 17:3855–3873

5. Kurochkina VB, Sklyarenko AV (2008) Enzymatic synthesis of beta-lactam antibiotics. Analytical review. In: Zaikov GE (ed) Biotechnology state of the art and prospects for development, Chap. 20. Nova Science Publishers, New York, pp 175–204

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