Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging
Author:
Funder
BE-Basic Foundation
Publisher
Springer Science and Business Media LLC
Subject
General Medicine,Bioengineering,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s00449-019-02239-x.pdf
Reference66 articles.
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2. Mahler H-C, Friess W, Grauschopf U, Kiese S (2009) Protein aggregation: pathways, induction factors and analysis. J Pharm Sci 98:2909–2934. https://doi.org/10.1002/jps.21566
3. Rosenberg AS (2006) Effects of protein aggregates: an immunologic perspective. AAPS J 8:E501–E507. https://doi.org/10.1208/aapsj080359
4. Wang W (2005) Protein aggregation and its inhibition in biopharmaceutics. Int J Pharm 289:1–30. https://doi.org/10.1016/j.ijpharm.2004.11.014
5. Philo JS, Arakawa T (2009) Mechanisms of protein aggregation. Curr Pharm Biotechnol 10:348–351. https://doi.org/10.2174/138920109788488932
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1. Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies;European Journal of Pharmaceutics and Biopharmaceutics;2021-08
2. Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination;Bioprocess and Biosystems Engineering;2020-11-25
3. Investigation of the reversibility of freeze/thaw stress-induced protein instability using heat cycling as a function of different cryoprotectants;Bioprocess and Biosystems Engineering;2020-03-20
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