Machine Learning Attempts for Predicting Human Subcutaneous Bioavailability of Monoclonal Antibodies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology
Link
http://link.springer.com/content/pdf/10.1007/s11095-021-03022-y.pdf
Reference51 articles.
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2. Datta-Mannan A, Estwick S, Zhou C, Choi H, Douglass NE, Witcher DR, et al. Influence of physiochemical properties on the subcutaneous absorption and bioavailability of monoclonal antibodies. mAbs. 2020;12(1):1770028.
3. Chan LJ, Bulitta JB, Ascher DB, Haynes JM, McLeod VM, Porter CJH, et al. PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of Trastuzumab in rats but increases plasma clearance after subcutaneous administration. Mol Pharm. 2015;12(3):794–809.
4. Frost GI. Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration. Expert Opinion Drug Deliv. 2007;4(4):427–40.
5. Fathallah AM, Turner MR, Mager DE, Balu-Iyer SV. Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration. Biopharm Drug Dispos. 2015;36(2):115–25.
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