Critical Evaluation of Human Oral Bioavailability for Pharmaceutical Drugs by Using Various Cheminformatics Approaches

Author:

Kim Marlene T.,Sedykh Alexander,Chakravarti Suman K.,Saiakhov Roustem D.,Zhu Hao

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Reference47 articles.

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2. Andrews CW, Bennett L, Yu LX. Predicting human oral bioavailability of a compound: development of a novel quantitative structure-bioavailability relationship. Pharm Res. 2000;17:639–44.

3. Moda TL, Montanari CA, Andricopulo AD. Hologram QSAR model for the prediction of human oral bioavailability. Bioorgan Med Chem. 2007;15:7738–45.

4. Ma CY, Yang SY, Zhang H, Xiang ML, Huang Q, Wei YQ. Prediction models of human plasma protein binding rate and oral bioavailability derived by using GA–CG–SVM method. J Pharmaceut Biomed. 2008;47:667–82.

5. Tian S, Li Y, Wang J, Zhang J, Hou T. ADME evaluation in drug discovery. 9. Prediction of oral bioavailability in human based on molecular properties and structural fingerprints. Mol Pharm. 2011;8:841–51.

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