Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2-Reference-Cited by-同舟云学术

Evaluation of the Utility of Chimeric Mice with Humanized Livers for the Characterization and Profiling of the Metabolites of a Selective Inhibitor (YM543) of the Sodium-Glucose Cotransporter 2

Published:2017-02-13 Issue:4 Volume:34 Page:874-886
ISSN:0724-8741
Container-title:Pharmaceutical Research
language:en
Short-container-title:Pharm Res

Author:

Nakada Naoyuki^ORCID

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Organic Chemistry,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biotechnology

Link

http://link.springer.com/content/pdf/10.1007/s11095-017-2116-4.pdf

Reference25 articles.

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2. Yokono M, Tahara A, Kurosaki E, Yamajuku D, Kihara R, Imamura M, et al. Pharmacological characterization of YM543, a newly synthesized, orally active SGLT2 selective inhibitor. Endocr Res. 2013;38:168–83.

3. Kalasz H, Petroianu G, Hosztafi S, Darvas F, Csermely T, Adeghate E, et al. Medicinal chemistry of drugs with active metabolites following conjugation. Mini Rev Med Chem. 2013;13(11):1550–63.

4. Klimas R, Mikus G. Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide. Br J Anaesth. 2014;113(6):935–44.

5. Ram N, Kalasz H, Adeghate E, Darvas F, Hashemi F, Tekes K. Medicinal chemistry of drugs with active metabolites (N-, O-, and S-desalkylation and some specific oxidative alterations). Curr Med Chem. 2012;19(33):5683–704.

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