Synthesis of novel 2-phenyl-3-[2-(substituted amino) ethylamino] quinazolin-4(3H)-ones as a new class of H1-antihistaminic agents

Author:

Alagarsamy V.,Shyam Sundar P.,Gobinath M.,Nivedhitha S.,Parthiban P.,Shankar D.,Sulthana M. T.,Raja Solomon V.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference14 articles.

1. Alagarsamy V (2004) Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1-receptor blockers. Pharmazie 59:753–755

2. Alagarsamy V, Venkatesaperumal R, Vijayakumar S, Angayarkanni T, Pounammal P, Senthilganesh S, Kandeeban S (2002) Synthesis and pharmacological investigation of some novel 2-phenyl-3-(substituted methyl amino) quinazolin-4(3H)-ones as H1-receptor blockers. Pharmazie 57:306–307

3. Alagarsamy V, Solomon VR, Murugan M (2007) Synthesis and pharmacological investigation of novel 4-benzyl-1-substituted-4H-[1,2,4]triazolo[4,3-a]quinazolin-5-ones as new class of H1-antihistaminic agents. Bioorg Med Chem 15:4009–4015

4. Carr AA, Meyer DR (1982) Synthesis of terfenadine. Arzneimittelforschung 32:1157–1159

5. Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y (1996) Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist. Eur J Pharmacol 314:351–356

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