Design, cytotoxicity and toxicity of new thiophene and thieno [2,3-b] pyridine derivatives

Author:

Mohareb Rafat M.,Ibrahim Rehab A.

Funder

Scientific Research at King Saud University

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Reference20 articles.

1. Barnes DM, Haight AR, Hameury T, McLaughlin MA, Mei J, Tedrow JS, Toma JDR (2006) New conditions for the synthesis of thiophenes via the Knoevenagel/Gewald reaction sequence. Application to the synthesis of a multi-targeted kinase inhibitor. 62:11311–11319

2. Bozorov K, Ma HR, Zhao JY, Zhao HQ, Chen H, Bobakulov K, Xin XL, Elmuradov B, Shakhidoyatov K, Aisa HA (2014) Discovery of diethyl 2,5-diaminothiophene-3,4-dicarboxylate derivatives as potent anticancer and antimicrobial agents and screening of anti-diabetic activity: synthesis and in vitro biological evaluation. Eur J Med Chem 84:739–745

3. Calleja MC, Persoone G (1992) The potential of ecotoxicological tests for the prediction of acute toxicity in man as evaluated on the first ten chemicals of the M.E.I.C. programme. Atla 20:396–405

4. Carballo JL, Hernández-Inda ZL, Pérez P, Grávalos MDG (2002) A comparison between two brine shrimp assays to detect in vitro cytotoxicity in marine natural products. BMC Biotechnol 2(17):1–5

5. Chen HH, Gross S, Liao J, McLaughlin M, Dean T, Sly WS, Jesse A, May JA (2000) 2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit. Biorg Med Chem 8:957–975

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