Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules-Reference-Cited by-同舟云学术

Design, Synthesis, and Screening of Pyridothieno[3,2-b]indole and Pyridothieno[3,2-c]cinnoline Derivatives as Potential Biologically Active Molecules

Published:2022-03-02 Issue:14 Volume:54 Page:3249-3261
ISSN:0039-7881
Container-title:Synthesis
language:en
Short-container-title:Synthesis

Author:

Stroganova Tatyana A.¹,Vasilin Vladimir K.¹,Kanishcheva Eugeniya A.²,Dmitrieva Irina G.³,Taranenko Viktor V.⁴,Tumskiy Roman S.⁵^ORCID,Tumskaia Anastasiia V.⁶,Aksenov Nikolay A.⁷,Krapivin Gennady D.²

Affiliation:

1. Department of Bioorganic Chemistry and Technical Microbiology, Kuban State Technological University

2. Research Institute of Heterocyclic Compounds Chemistry, Kuban State Technological University

3. FSBSI All-Russian Research Institute of Biological Plant Protection

4. Department of Organic Chemistry, Kuban State Agrarian University

5. Institute of Biochemistry and Physiology of Plants and Microorganisms (IBPPM RAS), Russian Academy of Sciences

6. Chemistry Institute, Saratov State University

7. Department of Organic Chemistry, North Caucasus Federal University

Abstract

AbstractNew pyridothieno[3,2-b]indole and pyridothieno[3,2-c]cinnoline derivatives are designed and prepared from the corresponding 3-amino-2-arylthieno[2,3-b]pyridines. By a molecular docking method novel potential inhibitors of DNA gyrase B are identified among the thieno[2,3-b]pyridine derivatives. In addition, some of the prepared pyridothienoindoles exhibit in vivo antidote activity against the herbicide 2,4-D.

Funder

Ministry of Science and High Education of the Russian Federation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry,Catalysis

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1785-7191.pdf

Reference30 articles.

1. Synthesis of novel triazolothione, thiadiazole, triazole-functionalized furo/thieno[2,3-b]pyridine derivatives and their antimicrobial activity

2. Synthesis, preliminary structure–activity relationships, and in vitro biological evaluation of 6-aryl-3-amino-thieno[2,3-b]pyridine derivatives as potential anti-inflammatory agents

3. Synthesis and structure-activity relationship of 4-alkoxy-thieno[2,3-b]pyridine derivatives as potent alkaline phosphatase enhancers for osteoporosis treatment

4. Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors

5. A new series of HCV inhibitors based on a 2-(thieno[2,3b]pyridin-2-yl)-1,3,4-oxadiazole scaffold