Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study-Reference-Cited by-同舟云学术

Structural modification of ellipticine derivatives with alkyl groups of varying length is influential on their effects on human DNA topoisomerase II: a combined experimental and computational study

Published:2019-11-20 Issue:2 Volume:29 Page:189-198
ISSN:1054-2523
Container-title:Medicinal Chemistry Research
language:en
Short-container-title:Med Chem Res

Author:

Kuskucu M.,Akyildiz V.,Kulmány Á.,Ergün Y.,Zencir S.,Zupko I.,Durdagi S.,Zaka M.,Sahin K.,Orhan H.,Topcu Z.

Publisher

Springer Science and Business Media LLC

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics

Link

http://link.springer.com/content/pdf/10.1007/s00044-019-02472-9.pdf

Reference33 articles.

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2. Champoux JJ (2001) DNA topoisomerases: structure, function, and mechanism. Annu Rev Biochem 70:369–413

3. Chikamori K, Grozav AG, Kozuki T, Grabowski D, Ganapathi R, Ganapathi MK (2010) DNA topoisomerase II enzymes as molecular targets for cancer chemotherapy. Curr Cancer Drug Tar 10:758–777

4. Coban G, Zencir S, Zupkó I, Réthy B, Gunes HS, Topcu Z (2008) Synthesis and biological activity evaluation of 1H-benzimidazoles via mammalian DNA topoisomerase I and cytostaticity assays. Eur J Med Chem 44:2280–2285

5. Deane FM, O’Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO (2013) Synthesis and evaluation of novel ellipticines as potential anti-cancer agents. Org Biomol Chem 1:1334–1344

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