Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-κB-NLRP3 inflammation activation
Author:
Funder
the Key Program of Basic Research of Chaoyang hospital
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
https://link.springer.com/content/pdf/10.1007/s00221-020-05911-x.pdf
Reference31 articles.
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2. Ahmadi S, Razazan A, Nagpal R, Jain S, Wang B, Mishra SP, Wang S, Justice J, Ding J, McClain DA, Kritchevsky SB, Kitzman D, Yadav H (2020) Metformin reduces aging-related leaky gut and improves cognitive function by beneficially modulating gut microbiome/goblet cell/mucin axis. J Gerontol A Biol Sci Med Sci 75:e9–e21
3. Alcocer-Gomez E, Cordero MD (2014) NLRP3 inflammasome: a new target in major depressive disorder. CNS Neurosci Ther 20:294–295
4. Alcocer-Gomez E, de Miguel M, Casas-Barquero N, Nunez-Vasco J, Sanchez-Alcazar JA, Fernandez-Rodriguez A, Cordero MD (2014) NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav Immun 36:111–117
5. Alcocer-Gomez E, Ulecia-Moron C, Marin-Aguilar F, Rybkina T, Casas-Barquero N, Ruiz-Cabello J, Ryffel B, Apetoh L, Ghiringhelli F, Bullon P, Sanchez-Alcazar JA, Carrion AM, Cordero MD (2016) Stress-induced depressive behaviors require a functional NLRP3 inflammasome. Mol Neurobiol 53:4874–4882
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